INFUSION OF CONVALESCENT PLASMA IS ASSOCIATED WITH CLINICAL IMPROVEMENT IN CRITICALLY ILL PATIENTS WITH COVID-19: A PILOT STUDY

Rev Invest Clin. 2020;72(3):159-164. doi: 10.24875/RIC.20000237.

Abstract

Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed.

Objective: The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center.

Methods: Ten patients were prospectively treated with plasma from COVID-19 convalescent donors.

Results: Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO2/FiO2) score increased from 124 to 255, (p < 0.0001), body temperature decreased significantly from 38.1 to 36.9°C (p = 0.0058), and ferritin levels also dropped significantly from 1736.6 to 1061.8 ng/ml (p = 0.0001). Chest X-rays improved in 7/10 cases and in 6/10, computerized tomography scans also revealed improvement of the lung injury. Decreases in C-reactive protein and D-dimer levels were also observed. Three of five patients on mechanical ventilation support could be extubated, nine were transferred to conventional hospital floors, and six were sent home; two patients died. The administration of CoPla had no side effects and the 24-day overall survival was 77%.

Conclusions: Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function.

Keywords: Convalescent plasma; Coronavirus disease-19; Severe coronavirus disease-19.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral / blood
  • Betacoronavirus* / immunology
  • Betacoronavirus* / isolation & purification
  • Biomarkers
  • Body Temperature
  • C-Reactive Protein / analysis
  • COVID-19
  • Combined Modality Therapy
  • Convalescence
  • Coronavirus Infections / blood
  • Coronavirus Infections / diagnostic imaging
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / therapy*
  • Female
  • Ferritins / blood
  • Humans
  • Immunization, Passive
  • Kaplan-Meier Estimate
  • Lung / diagnostic imaging
  • Male
  • Middle Aged
  • Pandemics
  • Pilot Projects
  • Plasma
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / diagnostic imaging
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / therapy*
  • Prospective Studies
  • Respiration, Artificial
  • SARS-CoV-2
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult

Substances

  • Antibodies, Viral
  • Biomarkers
  • C-Reactive Protein
  • Ferritins

Supplementary concepts

  • COVID-19 drug treatment
  • COVID-19 serotherapy