Successful Remission Induction Therapy With Gilteritinib in a Patient With De Novo FLT3-mutated Acute Myeloid Leukaemia and Severe COVID-19

Br J Haematol. 2020 Jun 25. doi: 10.1111/bjh.16962. Online ahead of print.

Abstract

The optimal treatment for patients with newly diagnosed acute myeloid leukaemia (AML) who are infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/COVID-19 is unknown.1 We report the case of a previously fit 27-year-old male who presented with a 3-day history of fever (>39 C), swollen, erythematous elbows and no respiratory symptoms. His white blood count (WBC) was 187×109 /L and bone marrow (Figure 1A & 1C) examination revealed normal karyotype AML with a fms related receptor tyrosine kinase 3 (FLT3) internal tandem duplication (ITD), wild-type NPM1 and no additional mutations on a next-generation sequencing panel.

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