Sociodemographic, Clinical and Laboratory Factors on Admission Associated With COVID-19 Mortality in Hospitalized Patients: A Retrospective Observational Study

PLoS One. 2020 Jun 25;15(6):e0235107. doi: 10.1371/journal.pone.0235107. eCollection 2020.

Abstract

Background: To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain.

Methods and findings: This retrospective case series included 238 patients hospitalized for COVID-19 at Hospital Universitario Clínico San Cecilio (Granada, Spain) who were discharged or who died. Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each patient. Associations between mortality and baseline characteristics were estimated as hazard ratios (HR) calculated with Cox regression models. Series mortality was 25.6%. Among patients with dependence for basic activities of daily living, 78.7% died, and among patients residing in retirement homes, 80.8% died. The variables most clearly associated with a greater hazard of death were age (3% HR increase per 1-year increase in age; 95%CI 1-6), diabetes mellitus (HR 2.42, 95%CI 1.43-4.09), SatO2/FiO2 ratio (43% HR reduction per 1-point increase; 95%CI 23-57), SOFA score (19% HR increase per 1-point increase, 95%CI 5-34) and CURB-65 score (76% HR increase per 1-point increase, 95%CI 23-143).

Conclusions: The patients residing in retirement homes showed great vulnerability. The main baseline factors that were independently associated with mortality in patients hospitalized for COVID-19 were older age, diabetes mellitus, low SatO2/FiO2 ratio, and high SOFA and CURB-65 scores.

Publication types

  • Research Support, Non-U.S. Gov't

Grant support

This work was supported by the SEMERGEN-UGR Chair of Teaching and Research in Family Medicine (Cátedra de Docencia e Investigación en Medicina de Familia SEMERGEN-UGR), University of Granada, Spain to MRI. The funder played no role in the study design, data collection or analysis, and decision to publish.