Serial neuropsychological testing in MOG antibody-associated disease to improve understanding of outcomes

Abstract

Neurocognitive outcomes data in patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease are limited. Within MOG-positive cohorts, outcomes data typically utilize gross psychological, cognitive, or physical disability measures. Here, we report a pediatric patient who presented with two clinically heterogeneous events and was found to have MOG-associated encephalomyelitis. We administered detailed neuropsychological test batteries to obtain a robust understanding of the patient's neurocognitive profile over time. This case exemplifies the need to perform systematic and serial neuropsychological testing in patients with MOG-associated disease to better understand neurocognitive outcomes, facilitate multidisciplinary management, and improve recovery.