Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds

Molecules. 2020 Jun 23;25(12):2895. doi: 10.3390/molecules25122895.


We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.

Keywords: cellular slime molds; dictyostelid; natural products; terpenoids.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Biosynthetic Pathways / drug effects
  • Dictyostelium / chemistry*
  • Dictyostelium / metabolism
  • Escherichia coli / drug effects
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microbial Sensitivity Tests
  • Osteogenesis / drug effects
  • RAW 264.7 Cells
  • Staphylococcus aureus / drug effects
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology


  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Terpenes