First Demonstration of Clinical Fusarium Strains Causing Cross-Kingdom Infections from Humans to Plants

Microorganisms. 2020 Jun 23;8(6):947. doi: 10.3390/microorganisms8060947.


Mycotoxins from the Fusarium genus are widely known to cause economic losses in crops, as well as high mortalities rates among immunocompromised humans. However, to date, no correlation has been established for the ability of Fusarium to cause cross-kingdom infection between plants and humans. The present investigation aims to fill this gap in the literature by examining cross-kingdom infection caused by Furasium strains isolated from non-immunocompromised or non-immunosuppressed humans, which were subsequently reinfected in plants and on human tissue. The findings document for the first time cross-kingdom infective events in Fusarium species, thus enhancing our existing knowledge of how mycopathogens continue to thrive in different hosts.

Keywords: horizontal cross-kingdom; keratomycosis; onychomycosis; pathogenicity.