Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. Hyperactivity of CD4-positive T cells?

Arthritis Rheum. 1988 Mar;31(3):401-7. doi: 10.1002/art.1780310312.


A significant enhancement of interleukin-2 production was observed in phytohemagglutinin-stimulated peripheral lymphocytes from patients with progressive systemic sclerosis (PSS). Their Leu-3a:Leu-2a ratio was also significantly higher than normal. Moreover, Leu-3a+ cells freshly purified from PSS patients' blood produced much more interleukin-2 than did cells from normal subjects. These results suggest that T cell hyperactivity, especially among Leu-3a+ T cells, occurs in patients with PSS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Antigens, Surface / analysis
  • Female
  • Flow Cytometry
  • Humans
  • Interleukin-2 / biosynthesis*
  • Kinetics
  • Leukocytes, Mononuclear / metabolism
  • Leukocytes, Mononuclear / physiology
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Scleroderma, Systemic / metabolism*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology*


  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Interleukin-2