Interstitial pneumonitis in antinuclear antibody-negative systemic lupus erythematosus: a new clinical manifestation and possible association with anti-Ro (SS-A) antibodies

Arthritis Rheum. 1988 Apr;31(4):545-8. doi: 10.1002/art.1780310412.


The clinical manifestations of patients with systemic lupus erythematosus (SLE) and negative fluorescent antinuclear antibody have been well documented. This report describes 2 cases of antinuclear antibody-negative SLE with antibodies only to Ro (SS-A) and the previously unreported clinical manifestation of lupus interstitial pneumonitis. A review of all SLE patients from 1984-1986 with interstitial pneumonitis revealed that 10 of the 12 patients had antibodies to Ro (SS-A). The frequency of anti-Ro (SS-A) with interstitial pneumonitis in SLE patients suggests a possible association between the two.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antinuclear / analysis*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Prednisone / therapeutic use
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / drug therapy
  • Pulmonary Fibrosis / etiology*
  • Pulmonary Fibrosis / immunology
  • Radiography


  • Antibodies, Antinuclear
  • SS-A antibodies
  • Prednisone