A Tale of Two Cities: Exploring the Role of Race/Ethnicity and Geographic Setting on PrEP Use Among Adolescent Cisgender MSM

AIDS Behav. 2021 Jan;25(1):139-147. doi: 10.1007/s10461-020-02951-w.


Although pre-exposure prophylaxis (PrEP) could substantially reduce the risk of HIV acquisition among adolescent cisgender men who have sex with men (cisMSM), various barriers faced by people of color, particularly within the southern region of the U.S., may lead to racial disparities in the utilization of PrEP. Few studies, however, have explored racial/ethnic differences in PrEP use by geographic setting among adolescent cisMSM. We conducted a cross-sectional analysis examining racial disparities in PrEP use among cisMSM ages 15-24 years in New Orleans, Louisiana, and Los Angeles, California recruited between May, 2017 and September, 2019. The odds of PrEP use among AA adolescents were considerably lower than White adolescents in New Orleans (OR (95% CI): 0.24 (0.10, 0.53)), although we did not find evidence of differences in Los Angeles. Our findings underscore the need for targeted interventions to promote PrEP use among adolescent MSM, particularly among AA adolescent cisMSM living in the southern region of U.S.

Keywords: Adolescent; Disparity; Men who have sex with men (MSM); Pre-exposure prophylaxis (PrEP); Race.

MeSH terms

  • Adolescent
  • Adult
  • Anti-HIV Agents* / therapeutic use
  • Cities
  • Cross-Sectional Studies
  • Disease Transmission, Infectious / prevention & control
  • Ethnicity
  • HIV Infections* / drug therapy
  • HIV Infections* / ethnology
  • HIV Infections* / prevention & control
  • Homosexuality, Male*
  • Humans
  • Los Angeles
  • Louisiana
  • Male
  • New Orleans
  • Pre-Exposure Prophylaxis*
  • Young Adult


  • Anti-HIV Agents