A comparison between propofol and ketamine for anaesthesia in the elderly. Haemodynamic effects during induction and maintenance

Anaesthesia. 1988 Mar;43 Suppl:109-11. doi: 10.1111/j.1365-2044.1988.tb09090.x.


The haemodynamic effects of propofol and ketamine were studied in two groups of eight randomly allocated elderly patients (mean age 85.8 years) anaesthetised for hip replacement. Group 1 patients patients received propofol 1 mg/kg by intravenous bolus for induction and 0.1 mg/kg/minute by continuous infusion for maintenance. Group 2 patients received ketamine 1.5 mg/kg by intravenous bolus as induction dose and 50 micrograms/kg/minute by continuous infusion for maintenance. All patients breathed spontaneously via a facemask at FIO2 1.0. Haemodynamic status was established before induction and at 1, 3, 5, 10 and 15 minutes after induction. Arterial pressure and cardiac output decreased slightly in group 1 but heart rate, right atrial pressure and pulmonary arterial pressure remained unchanged. Myocardial oxygen consumption showed a significant decrease of 27%. There was a significant increase in blood pressure and pulmonary capillary wedge pressure (by 97%) in group 2. Cardiac output and systemic vascular resistance remained unchanged whereas myocardial oxygen consumption showed a very significant increase of 100%.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia Recovery Period
  • Anesthesia, Intravenous*
  • Anesthetics / pharmacology*
  • Female
  • Hemodynamics / drug effects*
  • Hip Prosthesis
  • Humans
  • Ketamine / pharmacology*
  • Male
  • Phenols / pharmacology*
  • Propofol


  • Anesthetics
  • Phenols
  • Ketamine
  • Propofol