Molecular pharmacology of ciclesonide against SARS-CoV-2

J Allergy Clin Immunol. 2020 Aug;146(2):330-331. doi: 10.1016/j.jaci.2020.05.029. Epub 2020 Jun 13.

Authors

Hirokazu Kimura¹, Hiromu Kurusu², Mitsuru Sada², Daisuke Kurai³, Koichi Murakami⁴, Wataru Kamitani⁵, Haruyoshi Tomita⁶, Kazuhiko Katayama⁷, Akihide Ryo⁸

Affiliations

¹ Department of Health Science, Gunma Paz University Graduate School of Health Sciences, Gunma, Japan. Electronic address: kimhiro@nih.go.jp.
² Advanced Medical Science Research Center, Gunma Paz University, Gunma, Japan.
³ Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.
⁴ Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
⁵ Department of Infectious Diseases and Host Defense, Gunma University Graduate School of Medicine, Gunma, Japan.
⁶ Department of Bacteriology, Gunma University Graduate School of Medicine, Gunma, Japan.
⁷ Laboratory of Viral Infection I, Kitasato Institute for Life Sciences Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
⁸ Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan.

No abstract available

Publication types

Letter

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / metabolism
Antiviral Agents / pharmacology*
Betacoronavirus / drug effects*
Betacoronavirus / enzymology
Betacoronavirus / genetics
Binding Sites
COVID-19
Coronavirus Infections / drug therapy
Coronavirus Infections / virology
Endoribonucleases / antagonists & inhibitors*
Endoribonucleases / chemistry
Endoribonucleases / genetics
Endoribonucleases / metabolism
Gene Expression
Glucocorticoids / chemistry
Glucocorticoids / metabolism
Glucocorticoids / pharmacology*
Humans
Molecular Dynamics Simulation
Pandemics
Pneumonia, Viral / drug therapy
Pneumonia, Viral / virology
Pregnenediones / chemistry
Pregnenediones / metabolism
Pregnenediones / pharmacology*
Protein Binding
Protein Interaction Domains and Motifs
Protein Structure, Secondary
RNA-Dependent RNA Polymerase / chemistry
RNA-Dependent RNA Polymerase / genetics
RNA-Dependent RNA Polymerase / metabolism
SARS-CoV-2
Structural Homology, Protein
Thermodynamics
Viral Nonstructural Proteins / antagonists & inhibitors*
Viral Nonstructural Proteins / chemistry
Viral Nonstructural Proteins / genetics
Viral Nonstructural Proteins / metabolism
Virus Replication / drug effects*

Substances

Antiviral Agents
Glucocorticoids
Pregnenediones
Viral Nonstructural Proteins
RNA-Dependent RNA Polymerase
Endoribonucleases
nidoviral uridylate-specific endoribonuclease
ciclesonide