Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors

Clin Infect Dis. 2021 Apr 8;72(7):1256-1258. doi: 10.1093/cid/ciaa883.


We report a case of a man with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details on this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.

Keywords: COVID-19; drug–drug interaction; hepatotoxicity; remdesivir.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • Adenosine Monophosphate / analogs & derivatives
  • Alanine / analogs & derivatives
  • Antiviral Agents / adverse effects
  • COVID-19 Drug Treatment*
  • Chemical and Drug Induced Liver Injury* / etiology
  • Humans
  • Male
  • SARS-CoV-2


  • ATP Binding Cassette Transporter, Subfamily B
  • Antiviral Agents
  • remdesivir
  • Adenosine Monophosphate
  • Alanine