A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

Yanhong Ma; Fanghao Cai; Yangyang Li; Jianghua Chen; Fei Han; Weiqiang Lin

doi:10.1016/j.bioactmat.2020.05.002

A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

Bioact Mater. 2020 Jun 15;5(3):732-743. doi: 10.1016/j.bioactmat.2020.05.002. eCollection 2020 Sep.

Authors

Yanhong Ma¹, Fanghao Cai¹, Yangyang Li², Jianghua Chen¹, Fei Han¹, Weiqiang Lin^{1

2}

Affiliations

¹ Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, 310003, China.
² Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.

Abstract

Chronic kidney disease (CKD) poses a great burden to global public health as current therapies are generally ineffective. Early detection and effective therapy are crucial for the future prevention and progression of CKD. Nanoparticles (NPs) vary by particle size, charge, shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties, targetability, or the bioavailability of drugs. Thus, the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD. This review describes the current experimental research, clinical applications of NPs, the current challenges, and upcoming opportunities in the diagnosis and treatment of CKD.

Keywords: Chronic kidney disease; Diagnosis; Nanoparticles; Treatment.

Publication types

Review