Stimulation of B-cell progenitors by cloned murine interleukin-7

Nature. 1988 Jun 9;333(6173):571-3. doi: 10.1038/333571a0.


The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / cytology*
  • Base Sequence
  • Cell Differentiation / drug effects*
  • Cloning, Molecular
  • DNA / genetics
  • Interleukin-7
  • Interleukins / genetics
  • Interleukins / pharmacology*
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / genetics


  • Interleukin-7
  • Interleukins
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/X07962