Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling

Science. 1988 Jun 10;240(4858):1546-8. doi: 10.1126/science.3259727.


Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Glycosylation
  • Humans
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / genetics
  • Kinetics
  • Membrane Glycoproteins / physiology*
  • Monocytes / metabolism*
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Tumor Necrosis Factor-alpha / genetics


  • Interleukin-1
  • Membrane Glycoproteins
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha