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. 2020 Aug 1;180(8):1120-1122.
doi: 10.1001/jamainternmed.2020.2227.

Association Between Penicillin Allergy Documentation and Antibiotic Use

Kimberly G Blumenthal  1   2   3 , Kristi Kuper  4 , Lucas T Schulz  5 , Tanaya Bhowmick  6 , Michael Postelnick  7 , Francesca Lee  8 , Rochelle P Walensky  2   3   9
Affiliations

Association Between Penicillin Allergy Documentation and Antibiotic Use

Kimberly G Blumenthal et al. JAMA Intern Med. .

Abstract

This cohort study assesses the prevalence and association of documented penicillin allergy with inpatient antibiotic use in the US.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Blumenthal reported intellectual property for a clinical decision support tool used institutionally for β-lactam allergy assessment at Partners HealthCare System, which is licensed to Persistent Systems. Dr Kuper reported being an employee of Vizient Inc at the time of the study. Dr Lee reported receiving grants from Lynntech outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Association of Documented Penicillin Allergies With Inpatient Antibiotic Use Among US Inpatients
Adjusted odds ratios (aORs) are adjusted for age, sex, race/ethnicity, length of hospitalization, number of staffed beds, hospital geographic location, diabetes, cephalosporin allergy, inpatient location within the hospital, and number of specific infections treated.
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References

    1. Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and management of penicillin allergy: a review. JAMA. 2019;321(2):188-199. doi:10.1001/jama.2018.19283 - DOI - PubMed
    1. MacFadden DR, LaDelfa A, Leen J, et al. . Impact of reported β-lactam allergy on inpatient outcomes: a multicenter prospective cohort study. Clin Infect Dis. 2016;63(7):904-910. doi:10.1093/cid/ciw462 - DOI - PubMed
    1. Bratzler DW, Dellinger EP, Olsen KM, et al. ; American Society of Health-System Pharmacists; Infectious Disease Society of America; Surgical Infection Society; Society for Healthcare Epidemiology of America . Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70(3):195-283. doi:10.2146/ajhp120568 - DOI - PubMed
    1. Trubiano JA, Vogrin S, Chua KYL, et al. . Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med. 2020;180(5):1-9. doi:10.1001/jamainternmed.2020.0403 - DOI - PMC - PubMed
    1. Barlam TF, Cosgrove SE, Abbo LM, et al. . Executive summary: implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):1197-1202. doi:10.1093/cid/ciw217 - DOI - PubMed

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