Less expression of CD4 + and CD8 + T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis

Clin Chim Acta. 2020 Nov;510:1-4. doi: 10.1016/j.cca.2020.06.040. Epub 2020 Jun 27.

Abstract

This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. Through this meta-analysis, we could draw a conclusion that less expression of blood CD4+ and CD8+ T cells count might reflect the severity of infection and often accompanied by a poor prognosis. Hence, we inferred blood CD4+ and CD8+ T cells count could be a promising biomarker for disease assessment and monitor of patients with COVID-19.

Keywords: CD4(+) T cells; CD8(+) T cells; COVID-19.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes / cytology*
  • CD8-Positive T-Lymphocytes / cytology*
  • COVID-19
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / immunology*
  • Female
  • Gene Expression Regulation*
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / immunology*
  • Prognosis