Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age

Int J Mol Sci. 2020 Jun 24;21(12):4479. doi: 10.3390/ijms21124479.


Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age.

Keywords: NAFLD; URAT-1; cardiovascular risk; children; fructose; hypertension; metabolic syndrome; uric acid.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Child
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / physiopathology*
  • Fructose / metabolism*
  • Humans
  • Hypertension / complications*
  • Hypertension / metabolism
  • Hypertension / pathology
  • Insulin Resistance
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / metabolism
  • Metabolic Syndrome / pathology
  • Obesity / complications*
  • Obesity / metabolism
  • Obesity / pathology
  • Risk Factors
  • Uric Acid / metabolism*


  • Uric Acid
  • Fructose