Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

Mar Drugs. 2020 Jun 24;18(6):329. doi: 10.3390/md18060329.

Abstract

Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide-peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.

Keywords: azole-based peptide; bioactivity; cyanobacteria; cytotoxicity; marine sponge; peptide synthesis; thiazole.

Publication types

  • Review