OKT4+ T cell abnormality in patients with active systemic lupus erythematosus: HLA-DR antigen expressions

Clin Immunol Immunopathol. 1988 Jul;48(1):42-9. doi: 10.1016/0090-1229(88)90155-9.

Abstract

The objective of this study was to define immunologic T cell abnormality characteristic of active systemic lupus erythematosus (SLE). Eight of nine patients who had severe clinical and laboratory manifestations of active SLE had a characteristically marked increase in OKT4+ and a decrease in OKT8+ T cells. Using OKIa1 and OKDR monoclonal antibody, we found that, in circulating blood of all patients with active SLE, an increased percentage of Ia+ and DR+ T cells is present compared to inactive SLE. Five of these active SLE patients had Tac+ antigens, an interleukin 2 receptor on OKT4+ and OKT8+ T cell subsets in resting blood. The present study demonstrates that Ia+ and DR+ antigens are selectively expressed on the majority of OKT4+ T cell subsets of all patients with active SLE, whereas Ia+ and DR+ antigens are expressed almost equally on both OKT4+ and OKT8+ T cell subsets in inactive SLE. The elevated percentage of Ia+, DR+, OKT4+ T cells in active SLE was accompanied by a highly depressed proliferative response to T cell mitogens, phytohemagglutinin and concanavalin A. However, OKT8+ T cell subsets in active SLE possessed a normal proliferative response to these T cell mitogens. We conclude that this abnormality of activated OKT4+ T cells bearing HLA-DR antigens may play a role in the development of active SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, Surface / analysis*
  • Antigens, Surface / biosynthesis
  • Female
  • HLA-D Antigens / analysis*
  • HLA-DR Antigens / analysis*
  • HLA-DR Antigens / biosynthesis
  • Histocompatibility Antigens Class II / analysis*
  • Histocompatibility Antigens Class II / biosynthesis
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Lymphocyte Activation
  • Male
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Surface
  • HLA-D Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II