doi: 10.1038/333742a0.
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
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- PMID: 3260350
- DOI: 10.1038/333742a0
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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
Nature.
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Abstract
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.
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