Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Nature. 1988 Jun 23;333(6175):742-6. doi: 10.1038/333742a0.

Abstract

The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Female
  • H-Y Antigen / genetics
  • H-Y Antigen / immunology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phenotype
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Sex Characteristics
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Monoclonal
  • H-Y Antigen
  • Receptors, Antigen, T-Cell