[Modulation of anticancer effects of immunochemotherapeutic agents in various nutritional environments]

Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):827-33.
[Article in Japanese]


It is well known that some kinds of immunological functions, s.c. NK activity, IFN or IL-2 production of spleen cells are decreased in mice with protein calorie malnutrition (PCM) compared with those of well-nourished mice. In this study, nutritional conditions of cancer bearers were demonstrated to have serious influence on the effects of immunochemotherapeutic agents as shown herewith. (1) Intra-tumoral 5-FU concentration was lower in PCM mice or starved mice than in mice fed a normal diet. (2) Transplanted mammary tumor, MM-48, was paradoxically grown in PCM mice after 7 days i.p. injection of OK-432 or Lentinan, but the tumor burden was relatively decreased after the same treatment in N-group mice. (4) The life prolongation effect of rIL-2 and OK-432 against ascitic hepatic carcinoma, MH-134, was recognized in C 3H/He mice. On the other hand, there was no observable effect by sequential i.p. injection of PCM mice sera together with rIL-2 and OK-432. (5) Clinically, a randomized study of advanced or recurrent gastric cancer patients treated with MMC and FT(MF) with or without Lentinan was performed. Excellent end-point results were obtained only in Lentinan-administered patients with normal protein levels, but no such effects were noted in patients with low protein levels (below 5.9 g/dl). These findings suggest that the nutritional environment of the cancer bearing host has an important role in the effect of some kinds of BRMs.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Animal Nutritional Physiological Phenomena
  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Biological Products / therapeutic use*
  • Humans
  • Interleukin-2 / therapeutic use*
  • Lentinan / therapeutic use*
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / therapy*
  • Nutritional Physiological Phenomena*
  • Picibanil / therapeutic use*
  • Polysaccharides / therapeutic use*
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / therapy*


  • Antineoplastic Agents
  • Biological Products
  • Interleukin-2
  • Polysaccharides
  • Lentinan
  • Picibanil