Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7

Michael Gütschow; Jean Jacques Vanden Eynde; Josef Jampilek; CongBao Kang; Arduino A Mangoni; Paola Fossa; Rafik Karaman; Andrea Trabocchi; Peter J H Scott; Jóhannes Reynisson; Simona Rapposelli; Stefania Galdiero; Jean-Yves Winum; Chiara Brullo; Katalin Prokai-Tatrai; Arun K Sharma; Matthieu Schapira; Yasu-Taka Azuma; Laura Cerchia; Mariana Spetea; Giangiacomo Torri; Simona Collina; Athina Geronikaki; Alfonso T García-Sosa; M Helena Vasconcelos; Maria Emília Sousa; Ivan Kosalec; Tiziano Tuccinardi; Iola F Duarte; Jorge A R Salvador; Massimo Bertinaria; Maurizio Pellecchia; Jussara Amato; Giulio Rastelli; Paula A C Gomes; Rita C Guedes; Jean-Marc Sabatier; Ana Estévez-Braun; Bruno Pagano; Stefano Mangani; Rino Ragno; George Kokotos; Margherita Brindisi; Florenci V González; Fernanda Borges; Mariarosaria Miloso; Jarkko Rautio; Diego Muñoz-Torrero

doi:10.3390/molecules25132968

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7

Molecules. 2020 Jun 28;25(13):2968. doi: 10.3390/molecules25132968.

Authors

Michael Gütschow¹, Jean Jacques Vanden Eynde², Josef Jampilek³, CongBao Kang⁴, Arduino A Mangoni^{5

6}, Paola Fossa⁷, Rafik Karaman^{8

9}, Andrea Trabocchi¹⁰, Peter J H Scott¹¹, Jóhannes Reynisson¹², Simona Rapposelli^{13

14}, Stefania Galdiero¹⁵, Jean-Yves Winum¹⁶, Chiara Brullo¹⁷, Katalin Prokai-Tatrai¹⁸, Arun K Sharma¹⁹, Matthieu Schapira^{20

21}, Yasu-Taka Azuma²², Laura Cerchia²³, Mariana Spetea²⁴, Giangiacomo Torri²⁵, Simona Collina²⁶, Athina Geronikaki²⁷, Alfonso T García-Sosa²⁸, M Helena Vasconcelos^{29

30

31}, Maria Emília Sousa^{32

33}, Ivan Kosalec³⁴, Tiziano Tuccinardi³⁵, Iola F Duarte³⁶, Jorge A R Salvador³⁷, Massimo Bertinaria³⁸, Maurizio Pellecchia³⁹, Jussara Amato¹⁵, Giulio Rastelli⁴⁰, Paula A C Gomes⁴¹, Rita C Guedes⁴², Jean-Marc Sabatier⁴³, Ana Estévez-Braun⁴⁴, Bruno Pagano¹⁵, Stefano Mangani⁴⁵, Rino Ragno⁴⁶, George Kokotos⁴⁷, Margherita Brindisi¹⁵, Florenci V González⁴⁸, Fernanda Borges⁴⁹, Mariarosaria Miloso⁵⁰, Jarkko Rautio⁵¹, Diego Muñoz-Torrero⁵²

Affiliations

¹ Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn, Germany.
² Formerly head of the Department of Organic Chemistry (FS), University of Mons-UMONS, 7000 Mons, Belgium.
³ Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.
⁴ Experimental Drug Development Centre, Agency for Science, Technology and Research, 10 Biopolis Road, Chromos, 05-01, Singapore 138670, Singapore.
⁵ Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide 5042, Australia.
⁶ Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01069 Dresden, Germany.
⁷ Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, 16132 Genova, Italy.
⁸ Pharmaceutical & Medicinal Chemistry Department, Faculty of Pharmacy, Al-Quds University, Jerusalem P.O. Box 20002, Palestine.
⁹ Department of Sciences, University of Basilicata, Viadell'Ateneo Lucano 10, 85100 Potenza, Italy.
¹⁰ Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 13, I-50019 Sesto Fiorentino, Florence, Italy.
¹¹ Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
¹² School of Pharmacy and Bioengineering, Keele University, Keele, Staffordshire ST5 5BG, UK.
¹³ Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
¹⁴ Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, 56126 Pisa, Italy.
¹⁵ Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
¹⁶ Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, 34296 Montpellier CEDEX 05, France.
¹⁷ Department of Pharmacy, Section of Medicinal Chemistry, University of Genoa, V.le Benedetto XV 3, I-16132 Genova, Italy.
¹⁸ Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
¹⁹ Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
²⁰ Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, 101 College St., Suite 700, Toronto, ON M5G 1L7, Canada.
²¹ Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
²² Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Sciences, 1-58 Rinku-ohraikita, Izumisano, Osaka 598-8531, Japan.
²³ Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS), National Research Council (CNR), 80131 Naples, Italy.
²⁴ Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
²⁵ Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni", via Giuseppe Colombo 81, 20133 Milano, Italy.
²⁶ Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
²⁷ Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
²⁸ Institute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.
²⁹ i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
³⁰ Cancer Drug Resistance Group-IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Rua Júlio Amaral de Carvalho, 45, 4200-135 Porto, Portugal.
³¹ Department of Biological Sciences, FFUP-Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
³² Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
³³ Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N 4450-208 Matosinhos, Portugal.
³⁴ Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10000 Zagreb, Croatia.
³⁵ Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
³⁶ Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
³⁷ Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
³⁸ Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy.
³⁹ Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA 92521, USA.
⁴⁰ Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy.
⁴¹ LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
⁴² iMed.Ulisboa and Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
⁴³ Institute of NeuroPhysiopathology, UMR 7051, Faculté de Médecine Secteur Nord, 51, Boulevard Pierre Dramard-CS80011, 13344-Marseille CEDEX 15, France.
⁴⁴ Departamento de Química Orgánica, Instituto Universitario de Bio-Orgánica (CIBICAN), Universidad de La Laguna, 38206 Tenerife, Spain.
⁴⁵ Department of Biotechnology, Chemistry and Pharmacy, DoE 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
⁴⁶ Department of Drug Chemistry and Technology, Rome Center for Molecular Design, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy.
⁴⁷ Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece.
⁴⁸ Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12080 Castelló, Spain.
⁴⁹ CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre 1021/1055, 4169-007 Porto, Portugal.
⁵⁰ School of Medicine and Surgery, Experimental Neurology Unit, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, MB, Italy.
⁵¹ School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
⁵² Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain.

Abstract

Breakthroughs in Medicinal Chemistry [...].

Publication types

Editorial

MeSH terms

Animals
Chemistry, Pharmaceutical
Drug Discovery / methods*
Humans
Molecular Targeted Therapy
Pharmaceutical Preparations
Structure-Activity Relationship

Substances

Pharmaceutical Preparations

Abstract

Publication types

MeSH terms

Substances

Grants and funding