Histopathological Features and Ann Arbor Stage in Periocular Lymphoma

In Vivo. 2020 Jul-Aug;34(4):1965-1974. doi: 10.21873/invivo.11993.


Background: To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL).

Patients and methods: A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018.

Results: OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048).

Conclusion: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival.

Keywords: Ann Arbor stage; Periorbital lymphoma; histopathology; ocular adnexal lymphoma; orbital lymphoma; survival.

MeSH terms

  • Adult
  • Conjunctival Neoplasms*
  • Eye Neoplasms* / pathology
  • Humans
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Orbital Neoplasms* / diagnosis
  • Orbital Neoplasms* / epidemiology
  • Orbital Neoplasms* / therapy
  • Prognosis
  • Retrospective Studies