Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells

Cancer Genet Cytogenet. 1988 Aug;34(1):77-88. doi: 10.1016/0165-4608(88)90171-9.


A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor beta chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q-, 6q-, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor alpha chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Surface / analysis
  • Cell Line
  • Chromosome Aberrations*
  • Chromosome Disorders*
  • DNA, Neoplasm / genetics
  • Humans
  • Karyotyping
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Nucleic Acid Hybridization
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / ultrastructure


  • Antibodies, Monoclonal
  • Antigens, Surface
  • DNA, Neoplasm