Rose Petal Extract ( Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects

J Med Food. 2020 Aug;23(8):870-878. doi: 10.1089/jmf.2020.4705. Epub 2020 Jun 30.


We sought to investigate the effect of extracts from Rosa gallica petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. In vivo study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.

Keywords: MMP-1 • Rosa gallica • skin whitening; melanin; wrinkle formation.

Publication types

  • Clinical Trial

MeSH terms

  • Cells, Cultured
  • Fibroblasts
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • MAP Kinase Signaling System / drug effects
  • Matrix Metalloproteinase 1 / metabolism
  • Melanins / metabolism
  • Melanoma, Experimental
  • Plant Extracts / pharmacology*
  • Rosa / chemistry*
  • Skin / drug effects*
  • Skin Aging / drug effects*
  • Skin Lightening Preparations / pharmacology*
  • Ultraviolet Rays


  • Melanins
  • Plant Extracts
  • Skin Lightening Preparations
  • JNK Mitogen-Activated Protein Kinases
  • MMP1 protein, human
  • Matrix Metalloproteinase 1