Nerve growth factor induces rapid redistribution of F-actin in PC12 cells

FEBS Lett. 1988 Aug 1;235(1-2):141-3. doi: 10.1016/0014-5793(88)81250-x.

Abstract

Nerve growth factor (NGF) induces the redistribution of F-actin in rat pheochromocytoma PC12 cells within 2-10 min, whereas epidermal growth factor (EGF) has no effect on microfilament organization. This redistribution of F-actin in PC12 cells is not protein synthesis dependent, but can be blocked by methyltransferase inhibitors.

Publication types

  • Comparative Study

MeSH terms

  • Actins / metabolism*
  • Adrenal Gland Neoplasms / metabolism*
  • Animals
  • Cycloheximide / pharmacology
  • Epidermal Growth Factor / pharmacology
  • Fluorescent Dyes
  • Kinetics
  • Methyltransferases / antagonists & inhibitors
  • Nerve Growth Factors / pharmacology*
  • Phalloidine
  • Pheochromocytoma / metabolism*
  • Rats
  • Rhodamines
  • Tumor Cells, Cultured

Substances

  • Actins
  • Fluorescent Dyes
  • Nerve Growth Factors
  • Rhodamines
  • Phalloidine
  • Epidermal Growth Factor
  • Cycloheximide
  • Methyltransferases