Activation of TLR7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential Therapy

Front Immunol. 2020 Jun 11:11:1373. doi: 10.3389/fimmu.2020.01373. eCollection 2020.

Authors

Konstantinos Poulas¹, Konstantinos Farsalinos¹, Charilaos Zanidis¹

Affiliation

¹ Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, Patras, Greece.

No abstract available

Keywords: COVID-19; Imiquimod (IMQ); SARS - CoV-2; immune activation; innate immunity.

MeSH terms

Adjuvants, Immunologic / therapeutic use*
Betacoronavirus / drug effects
Betacoronavirus / immunology*
COVID-19
COVID-19 Drug Treatment
Coronavirus Infections / drug therapy*
Coronavirus Infections / immunology
Coronavirus Infections / prevention & control
Drug Repositioning / methods
Humans
Imiquimod / therapeutic use*
Immunity, Innate / drug effects
Pandemics / prevention & control
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / immunology
Pneumonia, Viral / prevention & control
SARS-CoV-2
Toll-Like Receptor 7 / immunology*

Substances

Adjuvants, Immunologic
TLR7 protein, human
Toll-Like Receptor 7
Imiquimod