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Review
. 2020 Jun 29:9:F1000 Faculty Rev-653.
doi: 10.12688/f1000research.22092.1. eCollection 2020.

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han  1 , Jianfeng Wu  1 , John Silke  2   3
Affiliations
Review

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han et al. F1000Res. .

Abstract

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.

Keywords: MAPK; inflammation; p38; signalling.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. A diagram of the p38 pathway.
MKP, mitogen-activated protein kinase phosphatase; TAB1, TAK1-binding protein 1; Tyr, tyrosine.
See this image and copyright information in PMC

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Grants and funding

This work was supported by the National Natural Science Foundation of China (81788101, 31420103910 and 81630042 to J.H.), the 111 Project (B12001 to J.H.) and by an NHMRC fellowship (1107149) to JS.

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