Soluble Urokinase Plasminogen Activator Receptor: A Biomarker for Predicting Complications and Critical Care Admission of COVID-19 Patients

Mol Diagn Ther. 2020 Oct;24(5):517-521. doi: 10.1007/s40291-020-00481-8.


The novel coronavirus infection has spread worldwide, causing a wide spectrum of clinical manifestations. Most patients develop moderate clinical illness, but a substantial number will experience severe pneumonia, which may rapidly progress to acute respiratory distress syndrome and multiple organ failure. In this population, soluble urokinase plasminogen activator receptor (suPAR) could serve as a quick triage test and independent marker of clinical severity, hospital and intensive care unit admission, complications, and mortality.

MeSH terms

  • Biomarkers / metabolism
  • COVID-19
  • Coronavirus Infections / complications*
  • Coronavirus Infections / metabolism*
  • Critical Care / statistics & numerical data
  • Humans
  • Pandemics
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / metabolism*
  • Prognosis
  • Receptors, Urokinase Plasminogen Activator / metabolism*
  • Solubility


  • Biomarkers
  • Receptors, Urokinase Plasminogen Activator