Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

Am J Med. 1988 Feb;84(2):257-64. doi: 10.1016/0002-9343(88)90422-6.


Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activities of Daily Living
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / diagnostic imaging
  • Female
  • HLA-D Antigens / analysis*
  • HLA-DR Antigens / analysis*
  • HLA-DR Antigens / genetics
  • HLA-DR4 Antigen
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Rheumatoid Factor / analysis*


  • HLA-D Antigens
  • HLA-DR Antigens
  • HLA-DR4 Antigen
  • Rheumatoid Factor