Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology

Endocrinol Metab (Seoul). 2020 Jun;35(2):272-287. doi: 10.3803/EnM.2020.35.2.272. Epub 2020 Jun 24.


Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.

Keywords: Dwarfism, pituitary; Hormone replacement therapy; Hypopituitarism; Growth hormone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Growth Disorders / diagnosis*
  • Growth Disorders / drug therapy*
  • Hormone Replacement Therapy*
  • Human Growth Hormone / administration & dosage*
  • Human Growth Hormone / deficiency*
  • Humans
  • Practice Guidelines as Topic / standards*
  • Prognosis
  • Societies, Scientific


  • Human Growth Hormone