A Dipeptide-Based Hierarchical Nanoarchitecture with Enhanced Catalytic Activity

Chenlei Wang; Jinbo Fei; Keqing Wang; Junbai Li

doi:10.1002/anie.202006994

A Dipeptide-Based Hierarchical Nanoarchitecture with Enhanced Catalytic Activity

Angew Chem Int Ed Engl. 2020 Oct 19;59(43):18960-18963. doi: 10.1002/anie.202006994. Epub 2020 Aug 25.

Authors

Chenlei Wang^{1

2}, Jinbo Fei^{1

2}, Keqing Wang^{1

2}, Junbai Li^{1

2}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Colloid, Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.

PMID: 32618091
DOI: 10.1002/anie.202006994

Abstract

Achieving synthetic architectures with simple structures and robust biomimetic catalytic activities remains a great challenge. Herein, we explore a facile supramolecular assembly approach to construct a dipeptide-based hierarchical nanoarchitecture with enhanced enzyme-like catalytic activity. In this nanoarchitecture, nanospheres are put in a chain-like arrangement through coordination-driven directional self-assembly. The reversible transformation of anisotropic nanochains to isotropic nanospheres switches biomimetic activity. Notably, the assembled nanoarchitecture exhibits a high enzyme-like activity and remarkable long-term stability to promote hydroquinone oxidation, superior to the natural counterpart. This work will pave the way to develop reversible and reusable supramolecular biocatalysts with ordered hierarchical structures for accelerating chemical transformations.

Keywords: biocatalysis; hierarchical nanoarchitectures; peptides; self-assembly; supramolecular chemistry.

Publication types

Research Support, Non-U.S. Gov't