Is Obesity a Disease of Stem Cells?

Cell Stem Cell. 2020 Jul 2;27(1):15-18. doi: 10.1016/j.stem.2020.04.019.


Obesity disrupts physiological homeostasis and alters both systemic and local microenvironments that impact stem cell plasticity and impair regenerative capacity. We present growing evidence that reveals the bidirectionality of obesity-induced stem cell dysfunction and how the molecular changes in stem cells residing in obese environments may accelerate disease severity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Plasticity
  • Homeostasis
  • Humans
  • Obesity*
  • Stem Cells*