Rubbing Out Leukemia Stem Cells by Erasing the Eraser

Yuanming Cheng; Hanzhi Luo; Michael G Kharas

doi:10.1016/j.stem.2020.06.009

Rubbing Out Leukemia Stem Cells by Erasing the Eraser

Cell Stem Cell. 2020 Jul 2;27(1):3-5. doi: 10.1016/j.stem.2020.06.009.

Authors

Yuanming Cheng¹, Hanzhi Luo¹, Michael G Kharas²

Affiliations

¹ Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
² Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: kharasm@mskcc.org.

Abstract

In this issue of Cell Stem Cell, Shen et al. (2020) and Wang et al. (2020) independently identify the essential function of m⁶A demethylase ALKBH5 in maintaining myeloid leukemia stem cells. These studies expand the regulators of the epitranscriptome that are required for acute myeloid leukemia (AML) development.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

AlkB Homolog 5, RNA Demethylase
Carcinogenesis
Cell Self Renewal*
Humans
Leukemia, Myeloid, Acute*
Stem Cells

Substances

ALKBH5 protein, human
AlkB Homolog 5, RNA Demethylase

Abstract

Publication types

MeSH terms

Substances

Grants and funding