Disappearance of SARS-CoV-2 Antibodies in Infants Born to Women with COVID-19, Wuhan, China

Emerg Infect Dis. 2020 Oct;26(10):2491-2494. doi: 10.3201/eid2610.202328. Epub 2020 Jul 4.

Abstract

We report the detection and decline over time of severe acute respiratory syndrome coronavirus 2 antibodies in infants born to women with coronavirus disease. Among 11 infants tested at birth, all had detectable IgG and 5 had detectable IgM. IgG titers with positive IgM declined more slowly than those without.

Keywords: 2019 novel coronavirus disease; COVID-19; China; SARS-CoV-2; Wuhan; antibody; infant; passive immunity; respiratory infections; severe acute respiratory syndrome coronavirus 2; vertical transmission; viruses; zoonoses.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Betacoronavirus / immunology*
  • Betacoronavirus / isolation & purification
  • COVID-19
  • China
  • Coronavirus Infections / immunology*
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Infant
  • Infant, Newborn
  • Pandemics
  • Pharynx / virology
  • Pneumonia, Viral / immunology*
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology*
  • RNA, Viral / analysis*
  • Rectum / virology
  • SARS-CoV-2
  • Time Factors

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • RNA, Viral