Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management

Clin Liver Dis. 2020 Aug;24(3):389-403. doi: 10.1016/j.cld.2020.04.013. Epub 2020 Jun 3.


Focal nodular hyperplasia and hepatocellular adenoma are benign liver lesions that occur most frequently in women and may be found as incidental findings on imaging. hepatocellular adenomas may be infrequently associated with malignant progression or risk of rupture and as such, require surveillance or definitive treatments based on their size threshold. It is important clinically to differentiate these lesions, and utilizing imaging modalities such as contrast enhanced ultrasound or magnetic resonance imaging can be helpful in diagnosis. Further molecular subtyping of hepatocellular adenoma lesions may be beneficial to describe risk factors and potential future clinical complications.

Keywords: Focal nodular hyperplasia; Hepatic adenoma; Hepatocellular adenoma; Liver lesion.

Publication types

  • Review

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / genetics
  • Adenoma / metabolism
  • Adenoma / surgery*
  • Female
  • Focal Nodular Hyperplasia / complications
  • Focal Nodular Hyperplasia / diagnosis*
  • Focal Nodular Hyperplasia / therapy*
  • Humans
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / surgery*
  • Liver Transplantation
  • Minimally Invasive Surgical Procedures
  • Pregnancy
  • Pregnancy Complications, Neoplastic / therapy*