Human effector T cells express TOX-Not so "TOX"ic after all

Sci Immunol. 2020 Jul 3;5(49):eabc8272. doi: 10.1126/sciimmunol.abc8272.

Authors

Daniel T Utzschneider¹, Axel Kallies²

Affiliations

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
² Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. axel.kallies@unimelb.edu.au.

PMID: 32620561
DOI: 10.1126/sciimmunol.abc8272

Abstract

TOX expression is not restricted to exhausted T cells but a characteristic of all human effector CD8⁺ T cells.

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

MeSH terms

Animals
High Mobility Group Proteins / immunology*
Humans
T-Lymphocytes / immunology*

Substances

High Mobility Group Proteins
TOX protein, human