Association between periodontal disease, tooth loss and liver diseases risk

doi:10.1111/jcpe.13341

. 2020 Sep;47(9):1053-1063.

doi: 10.1111/jcpe.13341. Epub 2020 Jul 20.

Association between periodontal disease, tooth loss and liver diseases risk

You Chen¹, Yu-Chong Yang², Bao-Ling Zhu³, Cong-Cong Wu³, Rui-Fang Lin³, Xi Zhang³

Affiliations

¹ College of Stomatology, Dalian Medical University, Dalian City, China.
² National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Tianjin, China.
³ Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City, China.

PMID: 32621350
DOI: 10.1111/jcpe.13341

Association between periodontal disease, tooth loss and liver diseases risk

You Chen et al. J Clin Periodontol. 2020 Sep.

. 2020 Sep;47(9):1053-1063.

doi: 10.1111/jcpe.13341. Epub 2020 Jul 20.

Authors

You Chen¹, Yu-Chong Yang², Bao-Ling Zhu³, Cong-Cong Wu³, Rui-Fang Lin³, Xi Zhang³

Affiliations

¹ College of Stomatology, Dalian Medical University, Dalian City, China.
² National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Tianjin, China.
³ Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City, China.

PMID: 32621350
DOI: 10.1111/jcpe.13341

Erratum in

Corrigendum.
[No authors listed] [No authors listed] J Clin Periodontol. 2021 Apr;48(4):615. doi: 10.1111/jcpe.13422. J Clin Periodontol. 2021. PMID: 33878807 No abstract available.

Abstract

Aim: The purpose of this study is to assess the associations between periodontal disease, tooth loss and liver diseases.

Materials and methods: PubMed and Embase databases were utilized to search eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used as effect size to assess the associations between periodontal disease, tooth loss and liver diseases risk.

Results: Our results indicated positive associations between periodontal disease and non-alcoholic fatty liver disease (NAFLD) (OR = 1.19, 95% CI = 1.06-1.33), liver cirrhosis (OR = 2.28, 95% CI = 1.50-3.48) and elevated transaminase level risk (OR = 1.08, 95% CI = 1.02-1.15). Moreover, tooth loss could increase NAFLD (OR = 1.33, 95% CI = 1.12- 1.56) and liver cancer risk (OR = 1.34, 95% CI = 1.04-1.74), and every five increment in tooth loss was associated with 5% increased liver cancer risk (OR = 1.05, 95% CI = 1.01 - 1.10) with a linear relationship. In addition, tooth loss had a positive tendency towards liver cirrhosis risk (OR = 2.03, 95% CI = 0.85-4.85) although there was no statistical significance.

Conclusion: Periodontal disease and tooth loss are positively associated with liver diseases including NAFLD, elevated transaminase level, liver cirrhosis and liver cancer.

Keywords: cirrhosis; liver cancer; non-alcoholic fatty liver disease; periodontal disease; tooth loss.

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References

REFERENCES

1. Abnet, C. C., Kamangar, F., Dawsey, S. M., Stolzenberg-Solomon, R. Z., Albanes, D., Pietinen, P., … Taylor, P. R. (2005). Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers. Scandinavian Journal of Gastroenterology, 40, 681-687. https://doi.org/10.1080/00365520510015430
1. Abnet, C. C., Qiao, Y. L., Mark, S. D., Dong, Z. W., Taylor, P. R., & Dawsey, S. M. (2001). Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes & Control, 12, 847-854. https://doi.org/10.1023/a:1012290009545
1. Akinkugbe, A. A., Barritt, A. S., Cai, J., Offenbacher, S., Thyagarajan, B., Khambaty, T., … Slade, G. D. (2018). Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos. Journal of Periodontology, 89, 949-958. https://doi.org/10.1002/JPER.17-0579
1. Akinkugbe, A. A., Slade, G. D., Barritt, A. S., Cole, S. R., Offenbacher, S., Petersmann, A., … Holtfreter, B. (2017). Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania. Journal of Clinical Periodontology, 44, 1077-1087. https://doi.org/10.1111/jcpe.12800
1. Al-Shammari, K. F., Al-Ansari, J. M., Al-Melh, M. A., & Al-Khabbaz, A. K. (2006). Reasons for tooth extraction in Kuwait. Medical Principles and Practice, 15, 417-422. https://doi.org/10.1159/000095486

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[1] Abnet, C. C., Kamangar, F., Dawsey, S. M., Stolzenberg-Solomon, R. Z., Albanes, D., Pietinen, P., … Taylor, P. R. (2005). Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers. Scandinavian Journal of Gastroenterology, 40, 681-687. https://doi.org/10.1080/00365520510015430

[2] Abnet, C. C., Kamangar, F., Dawsey, S. M., Stolzenberg-Solomon, R. Z., Albanes, D., Pietinen, P., … Taylor, P. R. (2005). Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers. Scandinavian Journal of Gastroenterology, 40, 681-687. https://doi.org/10.1080/00365520510015430

[3] Abnet, C. C., Qiao, Y. L., Mark, S. D., Dong, Z. W., Taylor, P. R., & Dawsey, S. M. (2001). Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes & Control, 12, 847-854. https://doi.org/10.1023/a:1012290009545

[4] Abnet, C. C., Qiao, Y. L., Mark, S. D., Dong, Z. W., Taylor, P. R., & Dawsey, S. M. (2001). Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes & Control, 12, 847-854. https://doi.org/10.1023/a:1012290009545

[5] Akinkugbe, A. A., Barritt, A. S., Cai, J., Offenbacher, S., Thyagarajan, B., Khambaty, T., … Slade, G. D. (2018). Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos. Journal of Periodontology, 89, 949-958. https://doi.org/10.1002/JPER.17-0579

[6] Akinkugbe, A. A., Barritt, A. S., Cai, J., Offenbacher, S., Thyagarajan, B., Khambaty, T., … Slade, G. D. (2018). Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos. Journal of Periodontology, 89, 949-958. https://doi.org/10.1002/JPER.17-0579

[7] Akinkugbe, A. A., Slade, G. D., Barritt, A. S., Cole, S. R., Offenbacher, S., Petersmann, A., … Holtfreter, B. (2017). Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania. Journal of Clinical Periodontology, 44, 1077-1087. https://doi.org/10.1111/jcpe.12800

[8] Akinkugbe, A. A., Slade, G. D., Barritt, A. S., Cole, S. R., Offenbacher, S., Petersmann, A., … Holtfreter, B. (2017). Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania. Journal of Clinical Periodontology, 44, 1077-1087. https://doi.org/10.1111/jcpe.12800

[9] Al-Shammari, K. F., Al-Ansari, J. M., Al-Melh, M. A., & Al-Khabbaz, A. K. (2006). Reasons for tooth extraction in Kuwait. Medical Principles and Practice, 15, 417-422. https://doi.org/10.1159/000095486

[10] Al-Shammari, K. F., Al-Ansari, J. M., Al-Melh, M. A., & Al-Khabbaz, A. K. (2006). Reasons for tooth extraction in Kuwait. Medical Principles and Practice, 15, 417-422. https://doi.org/10.1159/000095486

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Association between periodontal disease, tooth loss and liver diseases risk

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Association between periodontal disease, tooth loss and liver diseases risk

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