Cell type-specific patterned neural activity instructs neural map formation in the mouse olfactory system

Neurosci Res. 2021 Sep;170:1-5. doi: 10.1016/j.neures.2020.06.007. Epub 2020 Jul 1.


The development of precise neural circuits is initially directed by genetic programming and subsequently refined by neural activity. In the mouse olfactory system, axons from various olfactory sensory neurons expressing the same olfactory receptor converge onto a few spatially invariant glomeruli, generating the olfactory glomerular map in the olfactory bulbs. Using the glomerular map formation as a model, this review summarizes the current understanding of mechanisms underlying topographic map development in the mouse olfactory system and highlights how neural activity instructs the map refinement process.

Keywords: Axon guidance; Gene expression; Neural activity; Neural circuit formation; Olfactory.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Mice
  • Olfactory Bulb / metabolism
  • Olfactory Receptor Neurons* / metabolism
  • Receptors, Odorant* / genetics
  • Receptors, Odorant* / metabolism


  • Receptors, Odorant