Cognitive disorders in people living with HIV

Lancet HIV. 2020 Jul;7(7):e504-e513. doi: 10.1016/S2352-3018(20)30107-7.


High rates of cognitive disorders in antiretroviral-treated people living with HIV have been described worldwide. The exact prevalence of such cognitive disorders is determined by the definitions used, and the presence of these cognitive disorders significantly impacts the overall wellbeing of people with HIV. With the cohort of people with HIV becoming increasingly older, and having high rates of comorbidities and concomitant medication use, rates of cognitive disorders are likely to increase. Conversely, interventions are being sought to reduce the size of the latent HIV reservoir. If successful, such interventions are likely to also reduce the HIV reservoir in the brain compartment, which could result in improvements in cognitive function and reduced rates of impairment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Retroviral Agents / therapeutic use*
  • Brain / virology
  • Cognition
  • Cognition Disorders / complications
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / etiology
  • Cognition Disorders / prevention & control
  • Cohort Studies
  • Comorbidity
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / virology
  • Humans
  • Prevalence
  • Virus Latency


  • Anti-Retroviral Agents