Implications for glycosylated compounds and their anti-cancer effects

Int J Biol Macromol. 2020 Nov 15:163:1323-1332. doi: 10.1016/j.ijbiomac.2020.06.281. Epub 2020 Jul 3.

Abstract

Glycosylated compounds are major secondary metabolites of plants, which have various therapeutic effects on human diseases, by acting as anti-cancer, antioxidant, and anti-inflammatory agents. Glycosylation increases stability, bioactivity, and solubility of compounds and improves their pharmacological properties. Two well-known examples of glycosylated compounds include cardiac and flavonoid, the anti-tumor activities of which have been emphasized by several studies. However, little is known about their role in the treatment or prevention of cancer. In this review, recent studies on anti-tumor properties of cardiac and flavonoid glycosides, and their mechanisms of action, have been investigated. More specifically, this review is aimed at focusing on the multifactorial properties of cardiac and flavonoid compounds as well as their correlation with signaling pathways in the treatment of cancer.

Keywords: Cardiac glycoside; Flavonoid glycoside; Glycosylated compounds.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Cardiac Glycosides / chemistry
  • Cardiac Glycosides / pharmacology
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / chemistry
  • Flavonoids / chemistry
  • Flavonoids / pharmacology
  • Glycosides / chemistry
  • Glycosides / pharmacology
  • Glycosylation
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plants / chemistry
  • Plants / metabolism
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / pharmacology
  • Secondary Metabolism

Substances

  • Anti-Inflammatory Agents
  • Cardiac Glycosides
  • Flavonoids
  • Glycosides
  • Plant Extracts
  • Protein Kinase Inhibitors
  • EGFR protein, human
  • ErbB Receptors