Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy

Leukemia. 2021 Mar;35(3):863-866. doi: 10.1038/s41375-020-0946-2. Epub 2020 Jul 4.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / metabolism*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Down Syndrome / drug therapy
  • Down Syndrome / metabolism
  • Down Syndrome / mortality*
  • Down Syndrome / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Maintenance Chemotherapy / mortality*
  • Male
  • Mercaptopurine / administration & dosage
  • Methotrexate / administration & dosage
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Survival Rate

Substances

  • Mercaptopurine
  • Methotrexate