Recurrent cutaneous Langerhans cell histiocytosis in infancy

Br J Dermatol. 1988 Aug;119(2):259-65. doi: 10.1111/j.1365-2133.1988.tb03210.x.


We report two infants, aged 4 and 9 months, respectively, who had recurrent cutaneous lesions of Langerhans cell histiocytosis confirmed by immunohistochemical and ultrastructural studies. The lesions were confined to the skin and appeared as transient papules on the trunk in both patients. Since neither showed evidence of internal organ involvement or further recurrences of the skin lesions during follow-up periods of 22 and 24 months, respectively, no therapy was given. These cases may be considered as an uncommon benign variant of the Langerhans cell proliferative disorder.

MeSH terms

  • Female
  • Histiocytosis, Langerhans-Cell / pathology*
  • Humans
  • Infant
  • Langerhans Cells / ultrastructure*
  • Microscopy, Electron
  • Recurrence
  • Skin Diseases / pathology*