The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

Cell. 1988 Oct 21;55(2):301-8. doi: 10.1016/0092-8674(88)90053-0.


The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation. We report our evaluation of the possible involvement of the lymphocyte-specific tyrosine kinase p56lck in these transduction pathways. Our data demonstrate that p56lck is specifically modulated with either CD4 or CD8 following antibody-mediated cross-linking of these molecules and that a large fraction of the total cellular lck protein can be coimmunoprecipitated with these surface glycoproteins. These results suggest that p56lck is functionally and physically associated with CD4/CD8 in normal murine T lymphocytes and support the concept that an independent signal is transduced by the interaction of these surface molecules with major histocompatibility complex determinants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / analysis*
  • Cell Line
  • Major Histocompatibility Complex
  • Mice
  • Protein-Tyrosine Kinases / analysis*
  • Signal Transduction*
  • T-Lymphocytes / analysis


  • Antigens, Differentiation, T-Lymphocyte
  • Protein-Tyrosine Kinases