Is CpG Density the Link between Epigenetic Aging and Lifespan?

Emily M Bertucci; Benjamin B Parrott

doi:10.1016/j.tig.2020.06.003

Is CpG Density the Link between Epigenetic Aging and Lifespan?

Trends Genet. 2020 Oct;36(10):725-727. doi: 10.1016/j.tig.2020.06.003. Epub 2020 Jul 2.

Authors

Emily M Bertucci¹, Benjamin B Parrott²

Affiliations

¹ Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA.
² Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA. Electronic address: benparrott@srel.uga.edu.

PMID: 32624337
DOI: 10.1016/j.tig.2020.06.003

Abstract

The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.

Keywords: DNA methylation; epigenetic aging; epigenetic potential; lifespan.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aging / genetics*
Animals
CpG Islands*
DNA Methylation*
Epigenesis, Genetic
Humans
Longevity / genetics*