Production of tumour necrosis factor and interleukin 1 by monocytes of patients with previous Yersinia arthritis

Clin Exp Immunol. 1988 Jun;72(3):410-4.


We studied production of tumour necrosis factor (TNF) and interleukin 1 (IL-1) by using purified peripheral blood monocytes of patients with previous yersinia arthritis (YA) and of healthy HLA-B27 positive and negative controls. Lipopolysaccharide-exposed cells of HLA-B27 positive and negative patients, and those of HLA-B27 positive controls, generated significantly more TNF than did HLA-B27 negative control cells. There was a positive correlation between the levels of TNF and IL-1. Our results give credence to the view that augmented production of phlogistic mediators may contribute to inflammatory symptoms in patients with HLA-B27 associated disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Infectious / etiology
  • Arthritis, Infectious / immunology*
  • Female
  • HLA-B Antigens / analysis
  • HLA-B27 Antigen
  • Humans
  • Indomethacin / pharmacology
  • Interleukin-1 / biosynthesis*
  • Lipopolysaccharides / pharmacology
  • Male
  • Middle Aged
  • Monocytes / immunology*
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Yersinia Infections / immunology*


  • HLA-B Antigens
  • HLA-B27 Antigen
  • Interleukin-1
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • Indomethacin