Circulating omentin-1 levels and inflammation in polycystic ovary syndrome

Ginekol Pol. 2020;91(6):308-312. doi: 10.5603/GP.2020.0057.

Abstract

Objectives: The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and inflammation in PCOS.

Material and methods: A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and sR-IL6 were measured in the fasting state.

Results: Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin- 1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.

Conclusions: Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines are factors modifying secretion of this adipokine.

Keywords: PCOS; inflammation; nutritional status; omentin-1.

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Cytokines / blood*
  • Female
  • GPI-Linked Proteins / blood
  • Humans
  • Insulin Resistance
  • Lectins / blood*
  • Middle Aged
  • Nutritional Status*
  • Obesity / blood*
  • Obesity / complications
  • Polycystic Ovary Syndrome / blood*
  • Polycystic Ovary Syndrome / complications

Substances

  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins