Chest pain without radiographic sacroiliitis in relatives of patients with ankylosing spondylitis

J Rheumatol. 1988;15(5):836-9.


The prevalence of complaints of thoracic pain or stiffness in the past 6 months was assessed by examination, HLA typing and sacroiliac radiographs in 420 relatives of 275 B27+ probands with ankylosing spondylitis (AS). AS or sacroiliitis was found in 15 of 420 relatives (3.6%). The gender of the proband did not influence the probability of AS or sacroiliitis among the relatives. In the absence of sacroiliitis, B27+ relatives had chest pain more often (31 of 208, or 14.9%) than B27- relatives (13 of 197, or 6.6%) (p less than 0.01). Chest pain assessed by questionnaire was associated with pain on pressure at the costosternal junctions. The concept of AS as a combination of radiographic sacroiliitis plus clinical signs or symptoms may be too narrow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Arthritis / complications
  • Arthritis / diagnostic imaging
  • Female
  • HLA-B Antigens / analysis
  • HLA-B27 Antigen
  • Humans
  • Male
  • Middle Aged
  • Pain / complications*
  • Radiography, Thoracic
  • Sacroiliac Joint / diagnostic imaging*
  • Spondylitis, Ankylosing / complications*
  • Spondylitis, Ankylosing / diagnostic imaging
  • Spondylitis, Ankylosing / genetics
  • Thorax*


  • HLA-B Antigens
  • HLA-B27 Antigen